This assignment is based on the Molecular Pathology Classification and Diagnosis lecture/podcast (slides attached). You should address each of the 4 points in slide 71, with roughly equal weighting to each of the 4 points. This outline is supported by slides 63, 69 and 70 and there is some directed reading to support the assignment within Course Content.
Specifically I would expect a complete answer to cover:
In particular, areas to be considered are:
1) Different subtypes (DLBCL, Burkitt lymphoma (BL), blastoid mantle cell lymphoma, lymphoblastic lymphoma)
2) Importance of myc translocation in diagnosis of BL
3) Double and triple hit DLBCL – now termed High-grade B-cell lymphomas, with and without MYC and BCL2 or BCL6 translocations
4) cell of origin classification of DLBCL ie ABC vs GC subtypes of DLBCL
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